A GROUP OF COMPOUNDS POSSESSING ANTICONVULSANT ACTIVITY IN THE MAXIMAL ELECTROSHOCK SEIZURE TEST
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چکیده
منابع مشابه
Enalapril enhances the anticonvulsant activity of lamotrigine in the test of maximal electroshock.
BACKGROUND The aim of this study was to find out whether angiotensin-converting enzyme (ACE) inhibitors, enalapril and cilazapril, affect the anticonvulsant action of some second-generation antiepileptics, lamotrigine (LTG), topiramate (TPM) and oxcarbazepine (OXC). METHODS The effects of ACE inhibitors on antiepileptic drugs were examined in the mouse model of maximal electroshock. RESULTS...
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15 صفحه اولInfluence of ethacrynic acid on the anticonvulsant activity of conventional antiepileptic drugs in the mouse maximal electroshock seizure model.
The aim of this study was to determine whether ethacrynic acid (EA), a loop diuretic with anticonvulsant activity, would affect the protective action of the conventional antiepileptics (AEDs) carbamazepine (CBZ), phenytoin (PHT), valproate (VPA) and phenobarbital (PB) in the mouse maximal electroshock seizure (MES) model. The effects of acute and chronic treatment with EA on these AEDs were exa...
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The present study was designed to investigate the pro- or anticonvulsant effect of tramadol using maximal electroshock (MES) test. An attempt was also made to determine the possible opioid receptor mechanism involved. MES seizures were induced through transauricular electrodes (60 mA, 0.2s) and the seizure severity was assessed by the duration of tonic hindlimb extensor phase. Intraperitoneal (...
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ژورنال
عنوان ژورنال: Japanese Journal of Pharmacology
سال: 1957
ISSN: 0021-5198
DOI: 10.1016/s0021-5198(19)65285-6